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Photo of Eugen Gheorghiu

Dr. Eugen Gheorghiu,

Director, International Center of Biodynamics, Bucharest, Romania

Curriculum Vitae

Education: PhD in Theoretical Physics, 1994, Institute for Atomic Physics - Bucharest, Romania
Professional Experience
2000–presentDirector, International Centre of Biodynamics, Bucharest
1997 - 2000 Director, National Institute for Research and Development for Biotechnologies– UNESCO Centre for Biodynamics, Bucharest, Romania
1996-1997Visiting Professor, Institute for Chemical Research (under JSPS), Kyoto University, Japan
1995-1996Scientific Director National Institute for Research and Development for Biotechnologies (NIBT), Bucharest, Romania and Head of Department of Equipments, Sensors an Informatics for Biotechnologies, within NIBT.
1993– presentProfessor/Senior Researcher 1st degree
1991–1996Head of Biophysics Laboratory -since 1993, Centre of Biotechnologies – BIOTEHNOS, Bucharest, Romania
1990–1994Associate Lecturer (since 1993- Associate Professor), University of Bucharest, Faculty of Physics, Bucharest, Romania
1989–1991Scientific Researcher, I.C.P.E.A.R. – Biophysics Laboratory, Bucharest, Romania
1984–1989Biophysicist and Scientific Researcher (since 1988), Radiation Biophysics Laboratory, Bucharest, Romania, Institute of Oncology

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His Topic of Materials' Days 2011:

High Sensitive Magneto-Electro-Optic detection platforms

Recent developments within the International Centre of Biodynamics concerning chip preparation as well as accomplishment of a measuring set-up allowing magneto-optic surface-plasmon-resonance (MOSPR1,2) assays are presented. The platform comprises the magneto-plasmonic sensor, the surface plasmon resonance detection module, the electromagnet providing the oscillating magnetic field (with controlled field strength and frequency) with actuation role for MOSPR and the flow-through chamber with integrated microfluidics.
The physical transduction principle is based on the combination of the magneto-optic activity of magnetic materials and plasmonic properties of selected metallic layers. The actual structure of layers was optimized using a Transfer Matrix approach3-5 based on the magneto-optical activity of the trilayers as a function of the thickness and position of the Cr, Co and Au layers, and has been constructed in house via physical vapor deposition of thin layers of Cr, Au and Co.
Such combination can produce a significant enhancement of the SPR effects that strongly depends on the optical properties of the surrounding medium, allowing its use for biosensing applications2. Calibration curves based on solutions with different refractive indices show a steeper slope in the case of the magneto-optical sensor proving an increased sensitivity. The sensing avenues emphasizing analytical capabilities of the platform e.g. to assess biomolecular reactions will be highlighted.
This work is supported by the NANOMAGMA FP7-214107-2 and National Project RoNanomagma.
Selected References
[1] B. Sepúlveda, A. Calle, L. M. Lechuga, and G. Armelles, Optics Letters, 31, 8 (2006) 1085-1087
[2] D. Regatos, D. Fariña, A. Calle, A. Cebollada, B. Sepúlveda, G. Armelles, and L. M. Lechuga, J. Appl. Phys. 108, 054502 (2010); doi:10.1063/1.3475711
[3] M. Born, E. Wolf, Principles of optics: electromagnetic theory of propagation, interference and diffraction of light, 6th ed.; Pergamon Press: Oxford; New York, 1980.
[4] M. Gheorghiu, A. Olaru, A. Tar, C. Polonschii, E. Gheorghiu, “Sensing based on assessment of non-monotonous effect determined by target analyte: case study on pore forming compounds”, Biosensors and Bioelectronics, 24 (2009) 3517–3523
[5] A. Olaru, M. Gheorghiu, S. David, T. Wohland, E. Gheorghiu, “Assessment of the multiphase interaction between a membrane disrupting protein and a lipid membrane”, J. Phys. Chem. B, 113 (2009), 14369–14380
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Cellular Biosensors: towards a unitary, integrated (nano-bio) analytical platform

The concept of sensing and detection has to be readdressed in view of the huge number of analytes to be assayed to comply with Registration, Evaluation, Authorisation and Restriction of CHemicals (REACH) requirements for analysis, labeling and cytotoxicological assessment.
Aiming to advance highly sensitive biosensing systems to detect various analytes (from toxins to pathogen cells, including mixtures thereof) we have developed novel analytical platforms able to reveal subtle variations of biointerfaces encompassed by bioaffinity and hybrid cellular sensors. Such platforms comprise Flow Injection Analysis, allowing for time based combined Electrochemical and Optical assays.
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