| 08:15 | Registration & coffee |
| 08:45 | Welcome – Opening 9. Materials Days |
Prof. Dr. Wolfgang Schareck, Rector of Rostock University, Rostock, Germany
Mr. Christian Weiß, CEO Rostock Business, Rostock, Germany |
| 09:00 | Nanomedicine-nanotoxicology the Janus Face of Nanomaterials |
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| | - Why is 'nano' needed
- Three principles of nanotoxicology
- Safety by Design
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Dr. Peter Wick
Co-Head of Materials-Biology Interactions Lab, EMPA Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
more Information |
| 09:30 | Improved fixation of bisphosphonate-coated metal |
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| | - Systemic or local bisphosphonates reduce the early migration of joint prostheses
- Bisphosphonates can be applied to metal surfaces
- Bisphosphonates on dental implant surfaces improved fixation in a randomized clinical trial
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Prof. Per Aspenberg
Chair for Orthopedics, Linköping University Hospital, Linköping, Sweden
more Information |
| 10:00 | Why is tribology key for the success of total hip arthroplasties? |
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| | - Arthroplasties and patients’ expectation in 2013
- Limitations of total hip arthroplasties – importance of the tribology
- New trends in low wear solutions for total hip arthroplasties
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Dr. Claude Rieker
Director Scientific Affairs Zimmer GmbH, Winterthur, Switzerland
more Information |
| 10:30 | Refreshment break & networking |
| 11:00 | Optimized dental implant surfaces |
|
| | - Does the full ceramic implantbased restoration become a state of the art?
- High Translucent Zirconia Dental Restorations - Is esthetic and safety still a contradiction?
- The Microporous Ceramic Surface ZircaPore(R) - Clinical behaviour of the dental Ziraldent(R)implant with ZircaPore(R) Surface
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Mr. Franz Berghänel
Head of R&D, Metoxit AG, Thayngen, Switzerland
more Information |
| 11:30 | Beyond the phenomenological osseointegration |
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| | - Fine microstructure of bone-implant interface tells the story;
- Biological base of osseointegration;
- Criteria for screening potential materials;
- New concepts for the development of next generation of dental implants
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Prof. Dr. James Zhijian Shen
Berzelii Centre EXSELENT on Porous Materials, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
more Information |
| 12:00 | Nanocomposites for Dental Applications |
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| | - Nano-Hybrid-Technology as a basis for dental composites with maximized filler content resulting excellent physical properties and clinical performance
- Nanostructured inorganic-organic hybrid polymers as an innovative resin matrix for dental restoratives
- Caries control by fluorescence diagnostics through transparent nano-sealants
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Dr. Reinhard Maletz
Head of R&D, VOCO GmbH Cuxhaven
more Information |
| 12:30 | In vivo testing of surface modifications in temporary anchorage devices |
|
| | - The influence of a plasma-enhanced functional layer and a copper layer on osseointegration and microbiological effect is studied with orthodontic miniscrews in beagle dogs
- First results of this pilot study suggest that bone contact rates can be improved by plasmapolymer coating
- Coating itself does not seem to produce failure rates.
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Dr. med. dent. Anja Salbach
PolyClinic for Orthodontics, Rostock University, Rostock, Germany
more Information |
| 13:00 | Lunch & Networking |
| 14:00 | Challenging Requirements on Materials for Vascular Implants |
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| | - different stent materials for different applications
- challanges of design and manufacturing of stents
- demands on stent materials in future
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Mr. Markus Dammer
Development Engineer Vascular Intervention, CORTRONIK GmbH, Rostock, Germany
more Information |
| 14:25 | Percutaneuos intervention of aortic and mitral disease |
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| | - Aortic stenosis and mitral regurgitation are the predominant valvular diseases in developed countries.
- Contemporary standard of care is surgical valve replacement, respectively, repair.
- Percutaneous intervention of aortic and mitral disease has been proved as a valuable therapeutic alternative in high surgical risk patients.
- By overcoming some first generation material and design limitations, percutaneous therapy might become the future standard for a majority of patients with valvular heart disease.
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Dr. med. Ralf Birkemeyer
Cardiology, University Medical Center, Rostock. Germany
more Information |
| 14:50 | Long term in vivo functionality of polymeric biliary stents |
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| | - Biomineralization and biofilm formation on medical polymers
- Stent design and material influence the dwell time and the incrustation process
- Polymer coatings – new strategies in biliary stent development
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Dr. Mareike Warkentin
Materials for Medical Technology, Rostock University, Germany
more Information |
| 15:10 | Tools and devices for minimal- invasive image guided interventions |
|
| | - "You can only treat what you can see" - Image guided Interventions are the future of treatment.
- Functionalisation of threapy tools is the key technology for these treatment strategies
- This talk deals with the conditions and requirements for advanced image guided interventions
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Dipl.-Ing. Axel Boese
Medical Telematics and Medical Technology, Micro Systems Technology, Otto-von-Guericke University Magdeburg, Germany
more Information |
| 15:30 | Refreshment break & networking |
| 16:00 | The role of dental implant surface modifications on osseointegration and biofilm formation |
|
| | - Dental implants have to meet a hybrid function.
- Optimized surfaces for bone contact areas (osseointregration), transgingival areas (epithelial seal) and oral cavity contact areas (bacteria repellent) are needed.
- Examples of implant surface modifications and their effect on interfacial processes (wettability, hydration, conditioning by macromolecular films, cellular interactions) are shown.
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Prof. Dr. Jürgen Geis-Gerstofer
Medical Materials Science & Technology University Clinic Tübingen, Germany
more Information |
| 16:30 | Dental Adhesives - Achievements and Challenges |
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| | - General principles of formulation and modes of operation
- Pros and cons of various test procedures
- Market trends and challenges for future developments
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Dr. Matthias Schaub
R&D Dental Materials, Heraeus Kulzer GmbH, Wehrheim
more Information |
| 16:55 | Handling - it can make or break a product |
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| | - How to implement changes in dental materials and make the dentist see the benefits.
- Advantages and disadvantages of simplifying.
- Approaches to quantify "handling"
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Dr. Hans-Dieter Höhnk
Business Development, DMG Dental-Material Gesellschaft mbH, Hamburg, Germany
more Information |
| 17:20 | Qualitative and Quantitative Determination of Methacrylates in Dental Materials |
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| | - Role of dental materials based on methacrylates to human health
- Groups of methacrylates used in dental materials: base-monomers and co-monomers
- Analytical methods for qualitative and quantitative determination of methacrylates Results achieved by LC-MS and GC-MS
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Dr. Ing. Heidi Fleischer
Institut of Automation - Rostock University
more Information |
| 17:45 | Refreshment break & networking |
| 18:00 | Public Lecture: Dynamic MATERIALS Towards Functional Adaptive Materials |
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| | - Constitutional dynamic materials may be defined as materials whose components are linked through reversible covalent or non-covalent connections which may undergo constitutional variations in a given set of conditions.
- Because of their intrinsic ability to exchange, incorporate and rearrange their components, they may in principle select them in response to external stimuli or environmental factors and, therefore, behave as adaptive materials of either molecular or supramolecular nature.
- Constitutional Dynamic Chemistry introduces into the chemistry of materials a paradigm shift with respect to constitutionally static chemistry and opens new perspectives in materials science.
- A rich variety of novel architectures, processes and properties may be expected to result from the blending of supramolecular and molecular dynamic chemistry with materials chemistry, opening perspectives towards adaptive materials and technologies.
- more about this public lecture
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Prof. Jean Marie Lehn
Laboratoire de Chimie Supramoléculaire ISIS, Université Louis Pasteur, Strasbourg, France
more Information |
| 19:00 | End of symposium day one |
| 19:30 | Get-Together |
| 08:30 | Registration & coffee |
| 09:00 | Fibrous materials for implants and regenerative medicine |
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| | - Biocompatibility of fibers
- Functionalisation of medical textiles
- Textiles for implantation
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Prof. Dr. Michael Doser
Deputy director and Head of development in Biomedical Engineering, ITV Denkendorf Stuttgart, Germany
more Information |
| 09:30 | Materials for Liver Assist and Regeneration |
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| | - Membranes and Adsorbents for Albumin Dialysis
- Albumin Materials for Detoxification
- Biologicals for Biomodulation and Regeneration
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Prof. Dr. Jan Stange
Chairman of the Board, Albutec GmbH Rostock, Germany
more Information |
| 09:50 | Biocompatible supports for the removal of pathogens from human blood and/or plasma |
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| | - Supports for Apheresis matrices for transplantation and auto-immunity
- applications need to be clinically usable Despite available solutions
- there is still need for improvement A wish list is presented and discussed
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Dr. Klaus Eulitz
Miltenyi Biotec, Teterow, Germany
more Information |
| 10:10 | Liquid-Mangaement Systems for safe drug handling |
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| | - Safety for patients and users – new challenges
- Dimensions of innovation – material, design, surface
- Translation of Innovations into Medical devices
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Dr. Dirk Forberger,
Chairman of the Board, RoweMed AG, Parchim, Germany
more Information |
| 10:30 | Refreshment break & networking |
| 10:50 | Scanning Probe Microscopy to elucidate processes of hybrid nanostructures |
|
| | - The knowledge on properties, behaviour and interaction of single objects is crucial to the development of novel materials, electronic devices, drug delivery systems und biomolecular assays.
- Scanning Probe Microscopy methods are based on specific localized interactions between probe and sample.
- They allow to image, manipulate, and characterize spectroscopically individual objects such as atoms, clusters, molecules, protein, vesicles and organelles.
- Unique properties of nanoscopic objects such as polyoxometalate clusters, catalytic molecules, viral protein-nucleic acid complexes and biogenic magnetite nanocrystals will be elucidated.
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Prof. Dr. Sylvia Speller
Surface and Boundary Physics, Institute of Physics, Rostock University, Rostock, Germany
more Information |
| 11:20 | Hydroxyapatite surface engineering towards cell attachment |
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| | - Cell communication with the bioimplant surface is strongly contributed by the electrical fields.
- The capacities on contact less engineering and characterization of the hydroxyapatite surface electrical charge /potential are reviewed.
- The approaches give an ability to control immobilization of the osteoblastic cells
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Prof. Dr. Yuri Dekhtyar
Head of the Institute, Biomedical Engineering and Nanotechnologies Institute Riga Technical University, Riga, Latvia:
more Information |
| 11:50 | Electron microscopic imaging of the bone-implant-interface |
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| | - Discussion of preparation routines for ESEM and TEM investigations of the biomaterial/tissue interface with focus on hard tissues
- Presentation of Examples: Acrylic bone cements, HA-filled bone cements, nanocrystalline HA and porous implants
- Conclusion: Electron microscopy is a valuable tool for the monitoring of new therapies in regenerative medicine of bone and cartilage
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Dr. Sven Henning
Fraunhofer Institute for Mechanics of Materials IWM , Halle, Germany
more Information |
| 12:15 | Lunch & Networking |
| 13:15 | Magnetism meets Neuroscience: Magnetic Nanoparticles for peripheral nerve injury. |
|
| | - Nanomedicine brings the opportunity of new therapies for non-invasive repair of nerve injuries, based on functional magnetic nanoparticles.
- New concepts are based on the actuation at the single-cell level, remotely controlled drug release and the physics of drug-carrying nanoparticles in connection with cell metabolic pathways
- Laboratory results have shown that in vitro processing is possible, although the next step towards therapeutic strategies is still in its infancy
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Prof. Gerardo F. Goya Rossetti
Instituto de Nanociencia de Aragón (INA), Universidad de Zaragoza, Zaragoza, Spain
more Information |
| 13:45 | Thermal cancer therapy with magnetic nanoparticles: Opportunities and challenges |
|
| | - The anti-cancer benefits of heat therapy have been recognized for several thousand years, but technological barriers to target heat precisely to cancer cells have prevented widespread use.
- Magnetic nanoparticles can be used to target cancer cells directly for therapeutic heating or drug delivery.
- The promise and challenges inherent with this technology will be presented
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Prof. Dr. Robert Ivkov
Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, United States
more Information |
| 14:15 | Magnetic Nanoparticles for Stem Cell Manipulation |
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| | - The labeling of mesenchymal stem cells with magnetic nanoparticles allows their imaging, tracking and manipulation for diverse applications in regenerative medicine.
- Magnetic nanoparticles were designed with suitable magnetic properties for magnetic resonance and magnetic particle imaging and cell tracking, as well as with fluorophores for optical imaging..
- The surface design has a significant influence on the particle internalization into the stem cells by unspecific or targeted strategies..
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Dr. Cordula Grüttner,
Micromod Partikeltechnologie GmbH, Rostock, Germany
more Information |
| 14:45 | Refreshment break & networking |
| 15:00 | Localized nucleic acid delivery for therapeutic applications |
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| | - Concepts of nucleic acid therapies
- Magnetically targeted delivery of nucleic acids
- Gene-activated implants for tissue regeneration
- Transcript therapy using messenger RNA
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Prof. Dr. Christian Plank
Institute of Experimental Oncology and Therapy Research ,Technical University Munich, Germany
more Information |
| 15:30 | Thin films and microelectrode arrays for neuroprostetics |
|
| | - Thin-film fabrication methods offer great integration capabilities to fabricate neural interfaces for the restoration or treatment of lost body functions (e.g. sight).
- Material combinations as well as processing methods have hindered the long-term success of such devices. Residual stress and low adhesive properties lead to early failure of such devices.
- Adhesion promotion through SiC shows promising results in building metal-polymer laminates capable of working in a humid environment even after 2 years incubation in vitro.
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Dipl.Ing. Juan Ordonez
Biomedical Microtechnology, IMTEK, Universität Freiburg, Germany |
| 16:00 | Mechanically adaptive nanocomposites for neural interfacing |
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| | - Intracortical microelectrodes enable human patients to communicate with computers through thoughts.
- The inflammatory response to microelectrodes contributes to poor electrode reliability.
- Mechanical mismatch between microelectrodes and brain tissue can propagate inflammation.
- Mechanically adaptive materials can facilitate implantation into the brain, and chronic tissue compliance
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Prof. Jeffrey R.Capadona
Biomedical Engineering, Case Western Reserve University, Cleveland, United States
more Information |
| 16:30 | Closing remarks of the chairman & End of symposium |