Program 1. Day

June 4th 2015

08:30Registration & Coffee
09:00Welcome – Opening 8. Materials Days Prof. Dr. Wolfgang Schareck, Rector of Rostock University, Rostock, Germany
Mr. Christian Weiß, CEO Rostock Business, Rostock, Germany
09:15 Piezoelectricity of biopolymers and Wolff’s law in bone
  • Following the initial work on wood and bone in 1950’s, the study of piezoelectricity has been developed for biopolymers, polysaccharide, protein, and DNA, and optically active polymers such as poly-L-lactic acid.
  • Recent studies using Piezoresponse Force Microscope have revealed piezo-, pyro-, and ferro- electricity in various biopolymers.
  • Wolff’s law states that bone grows best to support the external stress.
  • It is once assumed that the electrical current due to the piezoelectricity in collagen might be the triggering signal.
Prof. Eiichi Fukada
Kobayasi Institute of Physical Research, Tokyo, Japan 
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09:45 Nanomagnetism in Biology and Medicine
  • The role of nanomaterials in modern healthcare
  • The challenges of establishing safety and understanding health risks
  • The role of academic innovation in the medical technologies sector
  • Fun things you can do with magnets
Prof Quentin Pankhurst
Institute of Biomedical Engineering, University College London, U.K. 
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10:15 Direct and indirect cell death induced by magnetic hyperthermia
  • The use of magnetic nanoparticles (MNPs), when incorporated into cells, provides a way for cell death due to energy supply by the electromagnetic fields under irradiation with radiofrequency waves; this is the field of magnetic hyperthermia (MHT).
  • In vitro cell models show that biodistribution of the nanoparticles constitutes a key factor for the existence of additional Indirect mechanisms that induce cell death of unloaded MNPs cells.
  • This indirect effect exists when the induced cell death occurs without increasing the macroscopic temperature of the cell culture under MHT.
  • This points to a new understanding of relevant biological and molecular mechanisms that trigger the cell death and it paves the way for new cancer therapies based on the use of non-ionizing radiation and nanotechnology as MHT.
Prof. M. Ricardo Ibarra
Universidad de Zaragoza, Spain and nB nanoScale Biomagnetics, Zaragoza, Spain  
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10:45Refreshment break & networking
11:15 Guided Bone Regeneration in Implant Dentistry
  • About 50% of dental implants are placed at sites with bone deficiencies and require therefore a bone augmention procedure.
  • Guided bone regeneration (GBR) is a technique used since 1988 to augment missing bone.
  • While a membrane serves as a physical barrier to keep away soft connective tissue, a bone filler provides mechanical support for the membrane and has many other functions.
  • Autologous bone and bone substitute materials, which are used as bone fillers, have very different properties.
Prof. Dr. sc. nat. Dieter Bosshardt
Schenk Laboratory of Oral Histology, University of Bern, Switzerland  
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11:45 Unraveling the Biophysical Cues in Cellular Organization
  • The differentiation and organization of cells during development occurs under the influence of spatially and temporally controlled soluble signal gradients
  • Macromolecules possess mechanical properties and structure and these attributes are postulated to play an important role in tailoring the biophysical aspects of a cellular environment.
Prof. V. Prasad Shastri
BIOSS and Institute for Macromolecular Chemistry, University of Freiburg, Freiburg 
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12:15 Rapid diagnostics of implant and tissue infections through a cartridge based system: a new approach
  • Diagnostic of prosthetic joint infections – a challenge for microbiology
  • Low grade infections
  • Antibiotic resistances in prosthetic joint infection
  • Diagnostics today and tomorrow/ The future of diagnostics
Dr. Torsten Wassermann
Curetis AG, Holzgerlingen  
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12:45Lunch & Networking
14:00 Stimulation of bone regeneration
  • Some therapeutical approaches are used to enhance bone regeneration.
  • Electrical stimulation of bone tissue is an interesting option for clinical treatment.
  • Different mechanisms of osteogenesis are discussed.
Prof. Dr. Rainer Bader
FORBIOMIT, Department of Orthopaedics, Rostock University, Rostock  
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14:20 Multiphysics simulation in bone mechanobiology: a predictive tool for implants evaluation
  • Multiphysics phenomena in bone mechanobiology: piezoelectricity and poroelasticity.
  • Modeling and simulation of bone remodelling, fracture healing and distraction.
  • Implant-tissue interactions: how to guide its integration.
Prof. Jose Manuel Garcia Aznar
Mechanical Engineering Dept, University of Zaragoza, Zaragoza, Spain 
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14:50 Towards active implant structures
  • electrical stimulation can improve osteogenesis
  • synthesis of piezoelectric ceramics by field assisted sintering technique
Mr. Rico Schnierer
Physics of New Materials, Rostock University, Rostock 
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15:10 Design and manufacture of hybrid implant material structures
  • Design criteria for hybrid metal-metal and metal-ceramic structures from a materials science perspective
  • Technologies for joining of dissimilar (implant) materials
  • Integrity of hybrid material structures
Dr. Christian Leinenbach
Laboratory for Joining Technology and Corrosion, EMPA, Dübendorf, Switzerland 
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15:40Refreshment break & networking
16:15 Resilient Bio-ceramics: Fracture and Reliability of Teeth and Dental Ceramics
  • Full ceramic partial dentures are aesthetic and bio-inert replacements, and a widely-accepted standard of care in dentistry nowadays, despite being rather brittle
  • Zirconia ceramics have a superior fracture-resistance than other ceramics due to the so-called transformation toughening mechanism.
  • Based on structure-function relationships we develop hierarchically structured ceramic compounds with the aim to increase their fracture toughness.
Prof. Dr.-Ing. Claudia Fleck
Institute of Material Sciences and Technologies, Technical University Berlin, Berlin 
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16:45 Improvement of wear testing methods for preclinical evaluate of joint implants
  • Decades ago wear was identified as one of the major reasons for long term failure of bearing implant designs.
  • Wear testing methods were developed since the introduction of modern joint implants to simulate their wear behavior preclinically.
  • The evolution of these testing methods during the last decade leads to complex simulations of high physiological demands.
  • The intension thereby is to avoid previously observed clinical failure modes and to evaluate material and design improvements of modern implants.
Jens Schwiesau
Innovation Biomechanical Research , Aesculap AG, Tuttlingen 
17:15 Titanium Casting and rapid prototyping
  • Titanium investment casting performed with the lost wax process meets the standards and demands of modern technology.
  • Cast parts guarantee an optimized use of material, give the ability to create complicated parts, a high level of precision, low wall thicknesses as well as a high level of cost savings on each part.
  • The ideal areas of application for investment castings are those where complicated inside contours, under cuts, hollow structures or bent surfaces cannot be produced or are too complicated to produce with other technologies.
  • Titanium cast parts from Rapid-Prototyping-Models meet the market’s demand for products manufactured to customer specifications within time and cost constraints.
Dr.-Ing. Christian Stöcker
R&D, Alcoa Power and Propulsion, Tital GmbH, Bestwig, Germany 
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18:00 Public Lecture: Materials and Structural Integrity: Milestone Aircraft Case Histories and Continuing Developments
  • Milestone aircraft accidents are discussed with respect to the integrity of conventional metallic structures.
  • These accidents have been especially influential and have caused paradigm shifts in structural integrity design and management.
  • Nowadays, developments in structural integrity have to include the implications of using new alloys, composites, and hybrid structures combining the respective advantages of metallic materials and composites.
Dr. Russell Wanhill
NLR - National Aerospace Laboratory, Emmeloord, The Netherlands  
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19:00End of symposium day one