Program 2. Day

June 5th 2015

08:00Registration & Coffee
08:30 Impact of Material and Surface Modifications on Osseointegration
  • The healing time of dental implants in partially edentulous patients has been steadily reduced in the last 15 years.
  • This great progress was primarily due to material science.
  • Surface topographie and chemistry influence both speed and extent of bone apposition on dental implants made of titanium.
  • Less is known about the influence of surface modifications on the speed of ossseointegration of other implant materials such as titanium alloys and zirconia.
Prof. Dr. sc. nat. Dieter Bosshardt
Schenk Laboratory of Oral Histology, University of Bern, Switzerland 
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09:00 Epitaxially-grown Designer Solids
  • Supramolecular chemistry holds unique prospects for the fabrication of novel functional materials
  • Its potential allows to construct three-dimensional, crystalline, perfectly ordered and oriented multilayers
  • Porous metal-organic frameworks (MOFs) rigidly anchored to solid surfaces, SURMOFs, open the prospect of adding additional functionality by placing nanoobjects inside the pores within the MOFs, e.g. metal clusters or dye molecules
  • The potential of these SURCOFs (surface-bound covalent organic frameworks) for life-science applications will be demonstrated
Prof. Dr. Christof Wöll
Institute of Functional Interfaces (IFG), KIT Karlsruhe Institute of Technology, Karlsruhe 
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09:30 Plasma enhanced adjustment of surface properties for biomedical applications
  • Every material interacts with its environment via its surface.
  • Controlling the surface properties of the material allows to enhance the properties of existing products and to create new kinds of them, also for multifunctional applications.
  • Particularly in the field of biomaterials a lot of of know-how has been generated within the last few years.
  • An overview of plasma based surface modifications for biomedical applications is presented.  
Dr. Maik Fröhlich
Bioactive Surfaces, INP Greifswald e.V. - FROM IDEA TO PROTOTYPE, Greifswald, 
10:00 Physicochemical properties of metal oxide nanoparticles: Role in inflammatory responses.
  • Development of engineered metal oxide nanoparticles (MNPs) with unique physicochemical properties is predicted to grow many-folds in the near future for commercial applications.
  • However, it is equally important to determining the human health-risks from exposure to these MNPs for regulating their exposure and for designing benign MNPs.
  • Inflammatory system is the sentry of the body against exposure to foreign pathogens and toxic substances, which if challenged can also lead to the development of chronic and acute-diseases.
  • It is important to determine the role of MNPs unique physicochemical properties in modulating inflammatory responses that may lead to short or long-term health related consequences.
Prof. Kunal Bhattacharya
Nanosafety§Nanomedicine Laboratory, Karolinska Institutet , Sweden 
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10:30Refreshment break & networking
11:00 Synthesis methods to prepare single- and multi-core iron oxide nanoparticles for biomedical applications
  • Different synthetic approaches will be described depending on their ability to generate magnetic particles that are either single-core or multi-core.
  • The aggregation state of the particles is of great relevance since the magnetic properties exibit a dramatic change with variations on the magnetic interactions between cores and with the surrounding matrix.
  • Multi-core particles seem to have superior performance for magnetic hyperthermia or MPI, although this fact is strongly affected by the chain or column formation of the particles within an applied magnetic field.
  • There are advantages of monodisperse single-core nanoparticles having uniform properties, for e.g. targeted delivery, since size determines its pharmacokinetic behaviour and its biodistribution.
Dr. Maria del Puerto Morales Herrero
Biomaterials and Bioinspired materials, Instituto de Ciencia de Materiales de Madrid, Madrid, Spain 
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11:30 NanoMag project - standardization of analysis methods for magnetic nanoparticles
  • The major objectives of the EU FP7 NanoMag project are to standardize, improve and redefine analysing methods of magnetic nanoparticles.
  • Novel synthesised magnetic nanoparticles with specific properties will be analysed with a multitude of analysis techniques.
  • Some of the analysis methods and recent results will be presented.
Prof. Christer Johansson
Sensor Systems,ACREO SWEDISH ICT AB, Göteborg, Sweden 
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12:00 The Layer-by-Layer (LbL) Technologie - a simple way for surface functionalization with nanometer precision.
  • The alternating adsorption of oppositely charged polymers or nanoparticles from aqueous solution yields homogeneous coatings in nanometer thickness on almost every surface.
  • The enormous amount of assembling materials allows a customized design of the surface properties and also the implementation of functional materials like drugs, biomolecules, imaging tracer molecules or nanoparticles possible.
  • If desired the semipermeable nature of the films can be used for sustained release of the materials and also for slow disintegration of the film by several triggers.
  • These unique properties will be demonstrated by several examples of LbL coatings.
Dr. habil. Lars Dähne
Surflay Nanotec GmbH, Berlin 
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12:30 Ink-jet printed polymer electrodes on bacterial cellulose for bioelectronic interfaces
  •  Ink-jet printing of polymers on biocompatible scaffolds is an interesting approach to fabricate implantable transducers which could be applied to brain-machine interfaces.
  • Inkjet-printed poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) electrodes on glass and on bacterial cellulose substrates  are particular suited to measure cell populations that  engage into cooperative activity.
  • Inkjet-printed poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) electrodes on glass and on bacterial cellulose substrates  are particular suited to measure cell populations that  engage into cooperative activity.
  • The relative electrode performance for electrophysiological measurements is discussed in terms of the cell/electrolyte interfacial impedance.
Prof. Henrique Gomes
Universidade do Algarve, Faro, Portugal 
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13:00Closing remarks of the chairman & End of symposium